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KMID : 0978920110120040170
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Korean Journal of Clinical Geriatrics
2011 Volume.12 No. 4 p.170 ~ p.175
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Elevated Plasma B-type Natriuretic Peptide Levels in Patients with Subcortical Vascular Dementia
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Kim Meyung-Kug
Yoo Bong-Goo
Kwon Su-Kyoung
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Abstract
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Background: B-type natriuretic peptide (BNP), a serum marker for congestive heart failure, is secreted by the cardiac ventricles in response to excessive stretching. Recent reports suggest that high BNP levels may predict cognitive dysfunction in older patients with cardiovascular disease. The BNP study for different type of dementia is very rare. The aim of the study was to compare the plasma BNP levels between Alzheimer’s disease (AD) and subcortical vascular dementia (SVaD) and to estimate the clinical significance of BNP for dementia.
Methods: We selected two groups of elderly with neurocognitive and functional impairment described as AD and SVaD. Obtained data were analyzed with respect to neuropsychological tests (Korean version of Mini-mental State Examination, Clinical Dementia Rating, and Global Deterioration Scale) and clinical parameters. We measured the plasma BNP levels in 73 patients with AD and 40 patients with SVaD.
Results: Neuropsychological tests did not differ significantly between patients with AD and SVaD. Compared with Alzheimer patients (56.5±45.7 pg/mL), BNP was elevated in subcortical vascular dementia (101.4±225.7 pg/mL, P=0.037). But no significant association was found between K-MMSE and BNP.
Conclusion: SVaD is associated with elevated BNP levels than AD. Elevated BNP probably reflects the larger cardiovascular burden in patients with SVaD. The result probably reflects the large amount of cardiovascular comorbidity in patients with subcortical vascular dementia.
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KEYWORD
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Alzheimer’s disease, Natriuretic peptide, Subcortical vascular dementia
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